Sunday, April 24, 2011

Beliefs Determine Behavior


The picture of President Obama is significant because it teaches us something about human nature - beliefs determine behavior.

People do not change their behaviors until they change their beliefs. If we desire a nation of health, energy, vitality, and fitness then we need to change our beliefs which in turn will change our behaviors.

I am sure that President Obama would agree with me that hot dogs are not a health food. The focus is not on the hot dog it is on the behavior.

Many us believe in moderation in all things. I would suggest moderation in all good things ALWAYS and moderation in all things NEVER!

If the health and wellness of this great Nation is going to change for the good than we will need to change our beliefs which in turn will change our behavior. It is behavior based upon our core beliefs that determine the consequences of our life. Take a moment and think about your behaviors and the consequences of your life and note how they are based upon your fundamental core beliefs.

In the words of Gandhi, "You must be the change you want to see."

For me I choose a an alkaline lifestyle and diet.

Saturday, April 23, 2011

Freedom of Health Speech and Conscience Amendment - The Food Freedom Amendment













The 112th Congress --
Help Educate Decision Makers!
Adopt Protective Legislation!
04.22.11 Update: Support H.R. 1364; Oppose S.216
Free Speech for Health & Food Claims!
Representatives: Please Reintroduce the
Provisions of these Bills from the 111th Congress:
H.R. 4913, the Free Speech About Science Act
H.R. 3394, the Freedom of Health Speech Act and
H.R. 3395, the Health Freedom Act

Freedom of Health Speech and Conscience Amendment
The Food Freedom Amendment

‎"Unless we put medical freedom into the Constitution, the time will come when medicine will organize itself into an undercover dictatorship. To restrict the art of healing to one class of men and deny equal privileges to others will constitute the Bastille of medical science. All such laws are un-American and despotic.” Dr. Benjamin Rush – Physician and Signer of the Declaration of Independence.

Our freedom of health is constantly under attack: UPDATE: S.216, Senator Leahy's (D-VT) disastrous and unconstitutional bill that would put anyone in jail for ten years if the FDA later decides your language about food was intentionally false and put people at risk. This bill has now passed the US Senate and has been sent over to the House. The food controllers have attempted to include this criminalization of speech about food bill in the so-called FDA "Food Safety" (actually food control) Modernization Act of 2010, but with regard to that provision and other similarly draconian provisions, our PUSH BACK worked... last year.

Now it's a new year and a new Congress are up to their old tricks! Please contact your Congress person immediately and let them know you want food freedom and your First Amendment rights respected and honored. Please disseminate this information as widely as possible: Our First Amendment AND Food Freedom, are at RisK! if this bill passes the House!

What is Food Freedom -- the right to obtain wholesome, natural foods (non-toxic, nonGMO) on the open market, produced as locally as possible -- is an important part of Health Freedom. The 111th Congress betrayed that Freedom by adopting the so-called FDA Food Safety [sic] Modernization Act, S.510-/HR.2751 - really a food control bill that attacks our local, wholesome food production and distribution. The new Congress must redress this grievance!

According to the World Health Organization, the chief world health problems are the "noncommunicable diseases of under and mal-nutrition" -- heart disease, diabetes, cancer and obesity. These appear to be "standard" conditions of modern life (to which we would add the world-wide plague of autism spectrum disorders, caused by exposing our children to intolerable levels of environmental toxins, including those present in vaccines and other drugs).

All of these conditions can be prevented and "treated" with natural, wholesome foods, including herbs, dietary supplements and natural remedies. Thus Food Freedom is a necessary ingredient in Health Freedom and the Innerlight Biological Health and Research Foundation seeks to educate decision makers... which means both officials and the public... about the need to provide legal protection for our Health and Food Freedoms -- to redress grievances and protect the public.

04.10.11 Update - H.R. 1364: We are pleased to note several members of Congress have introduced a new bill that incorporates some of the provisions for which we are urging support. The new bill allows manufacturers of dietary supplements and healthy foods to:

--Cite legitimate scientific research.
--Provide a clear definition of the types of research that may be referenced.
--Ensure that referencing such research does not convert a food or dietary supplement into an unapproved (and therefore illegal) new drug.
--Retain the authority of FDA and FTC to pursue any fraudulent and misleading statements.
This bill is entitled the Free Speech About Science Act (HR 1364) and was introduced in the House of Representatives April 2011 by Congressmen Jason Chaffetz (R-UT) and Jared Polis (D-CO).

Read more about the Bill on Foundation Trustee Ralph Fucetola JD's blog: HR 1364 and the Struggle for Health and Food Freedom
http://vitaminlawyerhealthfreedom.blogspot.com/2011/04/free-speech-about-science-act-hr-1364.html

In addition to pro-health and food freedom bills, Sen. Leahy introduced (and the Senate quickly passed) S.216 which increases criminal penalties for speech about food that the FDA later decides was false. This a very dangerous bill that ought to be stopped in the House!

S.216: "Any person who violates subsection (a), (b), (c), or (k) of section 301 with respect to any food -- (A) knowingly and intentionally to defraud or mislead; and (B) with conscious or reckless disregard of a risk of death or serious bodily injury, shall be fined under title 18, United States Code, imprisoned for not more than 10 years, or both."

Foods or dietary supplements that may be of benefit for health conditions are, according to the FDA, unapproved "drugs." Representatives Jason Chaffetz (R-UT) and Jared Polis (D-CO) the co-chairs of the Dietary Supplement Caucus, introduced the Free Speech about Science Act -- H.R. 4913 into the 111th Congress. This bill would ensure our basic Free Speech in health matter, end censorship and, according to observers, "enable the natural health products community to share peer-reviewed scientific findings about natural health products with the public..."

We have long urged support for Representative Ron Paul’s bills from the 111th Congress - HR 3394, the Freedom of Health Speech Act, and HR 3395, the Health Freedom Act.

Reintroducing these bills in the 112th Congress will offer the possibility of a real turn-around in US law; finally supporting the intent of the Dietary Supplement Health and Education Act of 1994 (DSHEA) that we have broad freedom to use food for heatlh and fully rejecting the FDA's discredited public policy of "HARMonizing" our rights with international Codex Alimentarius (so-called World Food Code) restrictions.

In addition, we support two other Health and Food Freedom Iniatives: (1) the Health Freedom Amendment and (2) the Food Freedom Amendment.

The Health Freedom Amendment is a complex proposal to amend US law and can be found in detail here: http://www.healthfreedomusa.org/?p=5359 --- some of its language outlined in the Details section below.

The Food Freedom Amendment is aimed at making it clear there is no Federal oversight authority with regard to local, non-factory-farm food production and distribution; this would greatly reduce the impact of the fake "Food Safety" act of 2010. This language would protect such food sources as organic or natural farms, community and home gardens, raw milk producers and the like. The wording of the Amendment is:

"No provision of Federal Law giving regulatory oversight to any Federal department or agency shall be deemed to apply (a) to any home, home-business, homestead, home or community gardens, small farm, organic or natural agricultural activity, (b) to any family farm or ranch, or (c) to any natural or organic food product, including dietary supplements, as protected under the Dietary Supplement Health and Education Act of 1994.”

The Free Speech about Science Act -- H.R. 4913 from the 111th Congress ought to be reintroduced in the new Congress, and this Action Item recommends that step to your representatives in Congress and asks them to become co-sponsors, moving this bill to rapid adoption. We also begin to educate Congress on the need to enshrine these important freedoms in the US Constitution, as the Freedom of Health Speech and Conscience Amendment!

But first, the bill starts with a "finding of fact" by Congress-

"The Congress finds the following:
(1) Federal regulators have forbidden--
(A) cherry growers and food producers to cite independent and respected scientific research on their produce that references health benefits; and
(B) a variety of dietary supplement makers to cite independent scientific research on health benefits from supplements from respected, peer-reviewed scientific journals.
(2) Americans want access and have a right to access legitimate scientific information about foods and dietary supplements to ensure informed decisions about diet and health care. While the American public is inundated daily with advertisements about prescription drugs for health conditions, many of which could be prevented through lifestyle changes, proper nutrition, and informed use of dietary supplements, Americans are denied access to the very information that assists in making informed lifestyle and health care decisions.
(3) Providing access to scientific information promotes self-responsibility, thereby empowering Americans to exercise independent judgment in caring for themselves and ultimately reducing health care costs and improving quality of life.
(4) The United States has a long commitment to the free dissemination of scientific research with the exception of limited extreme situations for national security. This commitment goes back to the First Amendment to the Constitution and has contributed vitally to the Nation's economic progress."

And then continues to hold that health claims should be permitted anytime,

"the claim is based on legitimate scientific research...mean[ing] scientific research, whether performed in vitro, in vivo, in animals, or in humans, that -- (i) is conducted in accordance with sound scientific principles; (ii) has been evaluated and accepted by a scientific or medical panel; and (iii) has been published in its entirety, or as an accurate, balanced summary or scientific review including a citation to the research in its entirety, in -- (I) a peer-reviewed article or book; (II) a recognized textbook; (III) a peer-reviewed scientific publication; or (IV) any publication of the United States Government (including ones published by or at the request of a Federal department, agency, institute, center, or academy)."

It's just that simple; legitimate scientific research without FDA and FTC bureaucrats preventing "truthful and not misleading" speech about the health benefits of natural solutions.

The Action Item below urges the adoption of this Free Speech about Science bill, Dr. Paul's two bills, and also introduces the concept of a Health Freedom Amendment. You can read more about the proposed Amendment at: http://www.healthfreedomusa.org/?p=5359 -- the proposed Amendment begins:

"No individual (including a minor through his or her parents) may be denied, by any person or agency acting under color of law: Access to any desired health care services, including those known as standard, conventional, alternative, advanced or complementary health care services, with fully informed consent; Access to all health care information for which there is at least a scintilla of evidence; Access to food, food components, contents or substances, including vitamins, minerals, amino acids, herbs, pro-biotics, pre-biotics, their precursors and metabolites; such components, content and/or substances may be offered with, or associated with, claims for their health benefits, without prior government approval and without limit as to mode of application..."

And continues (in part):

"No individual (including a minor through his or her parents) shall be exposed to genetically modified or degraded food without his or her consent... No individual (including a minor through his or her parents) shall be subject to involuntary medication (including vaccination) or any other involuntary medical treatment.."

For many years, the plan to capture – and kill – clean, local, organic, independent and safe farming, and impose the restrictions on Health and Food Freedom found in Codex Alimentarius (the so-called World Food Code) along the way, was pushed through Congress. Last year, the devastating HR.2751 (incorporating S.510) passed the lame-duck Congress and was signed by the White House, although we put up a good battle, delaying it for quite a while. Strong public PUSH BACK changed the bill, removing some of its most onerous provisions and adding in a few bits of small-production protection. The election of November 2010 shows that there is no longer any public support for this type of Federal power grab.

Now we think it is more than time to go on the offensive. We need to demand redress for our grievances and petition Congress to adopt laws to protect our Health and Food Freedoms from bureaucratic government interference.

Demand protection for your fundamental rights!

No Comment - No Entry - No Life


Fukushima_No_Comment_1000







No Comment
No-Entry Zone

END
23 04 2011 No Comment

Sur cette photo de 2002 libérée par The Yomiuri Shimbun, des techniciens examinent des équipements à l'intérieur du bâtiment du réacteur n° 4 de la centrale nucléaire de Fukushima Daiichi,
dans le nord-est du Japon. Le matin du mercredi 16 Mars 2011 la structure de ce bâtiment a été pulvérisée par l’explosion des tuyaux d’alimentation de refroidissement en eau radioactive
reliant la cuve du réacteur à la turbine, ce qui a provoqué une très importante libération dans l’environnement de matières radioactives.

In this 2002 photo (The Yomiuri Shimbun), workers examine equipments inside of the the No. 4 unit of the Fukushima Daiichi nuclear power plant in Okumamachi, northeastern Japan.
The outer housing of the containment vessel at the No. 4 unit at the Fukushima Dai-ichi nuclear complex erupted in flames early Wednesday March 16, 2011.

Des moines bouddhistes s’extériorisent au cours d’un sit-in face de la résidence officielle du Premier Ministre à Tokyo le 14 04 2011 pour exiger l'abolition des centrales nucléaires. (Koji Sasahara)

Buddhist monks chant sutras during their sit-in demanding the abolition of nuclear power plants in front of the prime minister's official residence in Tokyo Thursday, April 14, 2011. (Koji Sasahara)

Mikio Tadano, Sumire sa fille de 16 ans et sa femme Noriko résidents de Futaba sont photographiés dans un centre d'évacuation de Fukushima, au nord est du Japon.
Ayant survécu au séisme et au tsunami du 11 Mars 2011, la région de Futaba était presque intacte,
mais des milliers d’habitants ont dû être évacués en extrême urgence de la ville à la suite des sirènes d’alertes aux radiations issues de la centrale nucléaire de Fukushima Daiichi. (Hiro Komae)

Futaba residents Mikio Tadano, his daughter Sumire, 16, and his wife Noriko are photographed at an evacuation center in Fukushima, northeastern Japan.
Having survived the March 11, 2011 earthquake and tsunami, most of Futaba was intact,
but thousands had to evacuate the city in the wake of the radiation warnings from the neighboring Fukushima Dai-ichi Nuclear power station. (Hiro Komae)



Les habitants du village de Litate écoutent (ndlr: leurs vies va basculer) Norio Sugano leur Maire, à droite de dos, leur expliquer le plan gouvernemental d’évacuation immédiate à cause
des fortes quantités de rayonnements dans leur village qui est à environ 40 kilomètres (24 miles) de la centrale nucléaire de Fukushima Daiichi nucléaires. Mercredi 13 avril 2011. (Kyodo News)

Residents of Litate village listen to Mayor Norio Sugano,right back to camera, explain a government plan to evacuate residents from
the village that's about 40 kilometers (24 miles) from the radiation-spewing Fukushima Daiichi nuclear plant. Wednesday April 13, 2011. (Kyodo News)

Drapeau_francais_40_25
Flag_Japon 44 29
Radiation_Protection_Particules_Pluie_Poster_Fondamental_mini
Radiation_Protect_yourself_against_particles_Poster_Fundamental_Japanese_version_mini
Radiation_Protect_yourself_against_particles_Poster_Fundamental_mini

SANTÉ PUBLIQUE
RADIATION POSTER FONDAMENTAL
PROTÉGEZ-VOUS DES PARTICULES
ZOOM - TÉLÉCHARGEMENT

PUBLIC HEALTH
FUNDAMENTAL RADIATION POSTER
PROTECT YOURSELF AGAINST PARTICLES
ZOOM - LOADING

Radiations_Monographie_Effets_sante_valeurs_millisieverts_mSv

Effets sur la santé des radiations en fonctions de la dose (monographie)
Actuellement dans le monde l’essentiel est l’inhalation ou ingérer des particules radioactives.
Le contrôle de la radioactivité par des balises ne sert strictement à rien (IRSN), c’est de la basse désinformation des populations.

Air_Filtration_Systeme_news

Air Filtration System (particles) / Systèmes de filtration d'air (particules)
In Progress

2

NBC_Nuclear_Biological_Chemical_Protection_Europa_news


My Cat Survived An Infection without Medical Intervention

The following is an unsolicited testimony from Marisa Blumenfeld and
her cat using pHour salts to fight an infection while giving birth to kittens.

Marisa Blumenfeld April 23 at 10:09am Report

Just a little story if you have time. My cat had a kitten two weeks ago. I left the house and she was fine, walking around purring.. in labor and well. When I came back five hours later... I found her dragging herself around unable to use one of her back legs... I looked, and for whatever reason (possibly one of the dogs snipped at her ?? she got to close to their food? never happened before) she had a deep 1 inch cut on her belly??? Believe it or not, she was still happy to see me, and purred as I stroked her... I decided to sew her up. she let me?? maybe she had so much 'adrenaline' from the labor... but I put three loose stitches. about 1/8 of an inch apart. that night about six hours later, her labor resumed and she had two more kittens, her wound bled a little more from the inside.
I put your pHour salts in her water...Her wound was infected.. and she was bleeding on the inside still... I only stitched the skin.. I think she had torn muscle as well. On the second day I made her a soap/ cabbage leaf poultice (Alkaline!). She looked bad and had no use of her leg. I did this for two nights... and then had to go away. I left her lots of food and water, and hoped for the best....

It's been ten days... I got home last night and found her on my bed! With three fat kittens... She had full use of her leg, as if nothing had happened. Her wound is clean and almost all healed. infection free. One of the stitches broke... and air got into the wound.. I think that helped as well

Oh yes, she is no longer on my bed lol..

Don't think she would have healed so well with vet intervention... Couldn't have afforded it anyways. Thanks Dr Young... Without what I'd learned from you.. she would not have lived. Thanks...

Thursday, April 21, 2011

Stop Poisoning Yourself With Sugar!


All sugars are harmful, including sucrose, dextrose, glucose, maltose, fructose, honey, maple syrup, corn syrup, beet sugar, cane sugar, agave, just to name a few. The following article appeared in the New York Times discussing the work of Robert Lustig is a good start in educating the world on the dangers of ingesting any form of sugar.

My research suggests that ALL sugars are acidic waste products from the degeneration of matter. For example a banana becomes sweeter with sugar as it rots. This is the case for all organized matter when it deteriorates. Sugar is the acidic waste product of fermentation and rotting. The same thing happens with body cells as they breakdown - sugar or glucose is produced as a biological waste product. Just like carbon monoxide is the exhaust or acidic elimination of a car so glucose is the exhaust or acidic waste product of metabolism and cellular degeneration.

The human body needs NO sugar to function. The fact that we have blood sugar is no different than a car having exhaust of carbon monoxide when it is running. The body is constantly trying to chelate this toxic waste product and eliminate it through the four channels of elimination - respiration, defecation, urination and perspiration.

The body runs on electrons NOT sugar.

When energy is low that is low electrical energy NOT low blood sugar. When blood sugars are low and energy is low this is the time to energize the body with electron rich green foods NOT poison it or stimulating it with some form of sugar.

You can have no or low blood sugar levels with high electron levels and feel energetic. The need for sugar for energy is a medical myth. The theory that the brain runs on sugar is a medical myth. All cells in the human body run on electrons transported on a matrix of sodium. Our body is salted with sodium NOT sugar. Sugar cannot conduct electricity but sodium ions can!

When you have cravings for sugar this in reality is the craving for salt. Salt is necessary for the transfer or conductivity of electrons or energy from one cell to another cell.

For additional thoughts on this subject please read the following article that appeared in the New York Times called, "Is Sugar Toxic." I hope it will inspire you to stop poisoning yourself and your loved ones - especially our children with any form of sugar.

There is NO such thing as a healthy or good for your body sugar!

Wednesday, April 20, 2011

Acid Causes Inflammation That Can Lead To Cancer












"The increase of MicroRna-155 is the result of cellular breakdown due to an increase of metabolic, dietary, respiratory and environmental acids. Increased tissue acidity will lead to inflammation and long term inflammation will lead to cancer." Dr Robert O Young

ScienceDaily (Apr. 19, 2011) — A new study shows how inflammation can help cause cancer. Chronic inflammation due to infection or to conditions such as chronic inflammatory bowel disease is associated with up to 25 percent of all cancers.

This study by researchers at the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James) found that inflammation stimulates a rise in levels of a molecule called microRNA-155 (miR-155).

This, in turn, causes a drop in levels of proteins involved in DNA repair, resulting in a higher rate of spontaneous gene mutations, which can lead to cancer.

"Our study shows that miR-155 is upregulated by inflammatory stimuli and that overexpression of miR-155 increases the spontaneous mutation rate, which can contribute to tumorigenesis," says first author and post-doctoral researcher Dr. Esmerina Tili. "People have suspected for some time that inflammation plays an important role in cancer, and our study presents a molecular mechanism that explains how it happens."

"Our findings also suggest that drugs designed to reduce miR-155 levels might improve the treatment of inflammation-related cancers," Tili says.

The findings were published recently in the Proceedings of the National Academy of Sciences.

MicroRNAs form a large family of non-coding genes involved in many important cell processes. They carry out this function by suppressing the amount of particular proteins in cells, with each type of microRNA often affecting many different proteins.

MiR-155 is known to influence blood-cell maturation, immune responses and autoimmune disorders, and high levels of this molecule have been directly linked to the development of leukemias, and breast, lung and gastric cancers.

For this study, Tili and her colleagues examined the effects of inflammation-promoting substances such as tumor necrosis factor or lipopolysaccharide (found in the outer walls of bacteria) on miR-155 expression and on the frequency of spontaneous mutations in several breast-cancer cell lines.

When the researchers exposed breast-cancer cells to the two inflammatory factors the levels of miR-155 rose abnormally high, and the mutation rate increased two- to three-fold. To understand why, the investigators focused on the WEE1 gene, which stops the process of cell division to allow damaged DNA to be repaired.

The investigators learned that miR-155 also targets WEE1 and showed that high levels of miR-155 lead to low levels of WEE1. They reasoned that low levels of WEE1 allowed cell division to continue even when DNA damage is present, leading to a growing number of mutations.

"It is believed that cancer is caused by an accumulation of mutations in cells of the body," says principal investigator Dr. Carlo M. Croce, professor and chair of molecular virology, immunology and medical genetics, and director of the Human Cancer Genetics program the OSUCCC -- James. "Our study suggests that miR-155, which is associated with inflammation, increases the mutation rate and might be a key player in inflammation-induced cancers generally. This could make it an important therapeutic target."

Funding from the National Cancer Institute supported this research.

Croce is also the John W. Wolfe Chair in Human Cancer Genetics.

Other researchers involved in this study were Jean-Jacques Michaille, Dorothee Wernicke, Hansjuerg Alder, Stefan Costinean and Stefano Volinia of The Ohio State University.

Tuesday, April 19, 2011

Dr Young's Research Validated - Acids From Metabolism Causes Cancer


The following article found in Science Daily validates Dr. Young's acid theory for the cause of cancer and his treatment theory of using anti-oxidants to reverse or buffer acids that cause cancer such as ketones and lactates.

Key to Personalized Cancer Medicine Unlocked Using Tumor Metabolism

ScienceDaily (Apr. 17, 2011) — Identifying gene mutations in cancer patients to predict clinical outcome has been the cornerstone of cancer research for nearly three decades, but now researchers at the Kimmel Cancer Center at Jefferson have invented a new approach that instead links cancer cell metabolism with poor clinical outcome. This approach can now be applied to virtually any type of human cancer cell.

The researchers demonstrate that recurrence, metastasis, and poor clinical outcome in breast cancer patients can be identified by simply gene profiling cancer cells that are using ketones and lactate as a food supply.

These findings are reported in the April 15 online issue of Cell Cycle. The investigators are calling this new approach to personalized cancer medicine "Metabolo-Genomics."

High-energy metabolites have long been suspected to "fuel" aggressive tumor cell behavior. The researchers used this premise to generate a gene expression signature from genetically identical cancer cells, but one cell group was fed a diet of high-energy metabolites. These lactate- and ketone-induced "gene signatures" then predicted recurrence, metastasis, and poor survival.

So, it appears that what cancer cells are eating determines clinical outcome, not necessarily new gene mutations.

Michael P. Lisanti, M.D., Ph.D., Professor and Chair of Stem Cell Biology & Regenerative Medicine at Jefferson Medical College of Thomas Jefferson University and a member of the Kimmel Cancer Center at Jefferson, together with other researchers, found that treatment of human breast cancer cells with high-energy metabolites increases the expression of genes associated with normal stem cells, including genes upregulated in embryonic and neural stem cells.

What's more, lactate and ketones were found to promote the growth of normal stem cells, which has critical applications for stem cell transplantation and for a host of different human diseases. It appears that these metabolites increase "stemness" in cancer cells, which drives poorer outcomes.

"Tumors that are using the body's own nutrients (lactate and ketones) as "fuel" have a poorer outcome for patient survival, a behavior that now can be used to predict if a patient is at a high-risk for recurrence or metastasis," Dr. Lisanti said. "This is getting to the heart of personalized cancer medicine. Now, we have identified a panel of biomarkers that directly links cancer metabolism with targeted cancer therapy."

These findings suggest, according to the authors, that high-risk cancer patients (those whose cancer cells use high-energy metabolites) can be treated with new therapeutics that target oxidative mitochondrial metabolism, such as the antioxidant metformin, a drug that is also used to treat diabetes.

"Knowing the gene signatures of patients whose cancer cells are "eating" these metabolites (lactate and ketones) for fuel is a pivotal piece of new information that we can use to diagnose and treat cancer patients," said Martinez-Outschoorn, M.D., of the department of Medical Oncology at Thomas Jefferson University, and the lead author of the paper. "It's not just that we know those patients will have poor survival; we know that those patients are using mitochondrial metabolism, which is the type of energy metabolism that we should be targeting with new anti-cancer drugs."

The researchers propose that this new approach to diagnosis and subsequent treatment be called "Metabolo-Genomics" since it incorporates both cell metabolism and gene transcriptional profiling. This strategy could now be used to direct which patients receive a particular "tailored" anti-metabolic therapy.

Genetic markers, like expression of the mutationally activated HER2 gene, provide biomarkers that can be used to identify breast cancer patients at high-risk for recurrence or metastasis, and to modify their subsequent treatment with targeted therapies (i.e., herceptin, a drug used in aggressive breast cancers). But with "Metabolo-Genomics," it is now about using "global" cancer cell metabolism for these predictions.

"Just by feeding cancer cells a particular energy-rich diet, it changes their character, without introducing mutations or altering their genetic profile," Dr. Lisanti said. "We've only fed them high energy nutrients that help them to use their mitochondria, and this changes their transcriptional profile. It's a new biomarker for "lethal" cancers that we can now treat with the right drugs, such as the anti-oxidant metformin."

Dr. Lisanti and his colleagues believe that tumor metabolism is the new big picture for understanding how cancers undergo recurrence and metastasis.

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