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23 04 2011 No Comment
Sur cette photo de 2002 libérée par The Yomiuri Shimbun, des techniciens examinent des équipements à l'intérieur du bâtiment du réacteur n° 4 de la centrale nucléaire de Fukushima Daiichi,
dans le nord-est du Japon. Le matin du mercredi 16 Mars 2011 la structure de ce bâtiment a été pulvérisée par l’explosion des tuyaux d’alimentation de refroidissement en eau radioactive
reliant la cuve du réacteur à la turbine, ce qui a provoqué une très importante libération dans l’environnement de matières radioactives.
In this 2002 photo (The Yomiuri Shimbun), workers examine equipments inside of the the No. 4 unit of the Fukushima Daiichi nuclear power plant in Okumamachi, northeastern Japan.
The outer housing of the containment vessel at the No. 4 unit at the Fukushima Dai-ichi nuclear complex erupted in flames early Wednesday March 16, 2011.
Des moines bouddhistes s’extériorisent au cours d’un sit-in face de la résidence officielle du Premier Ministre à Tokyo le 14 04 2011 pour exiger l'abolition des centrales nucléaires. (Koji Sasahara)
Buddhist monks chant sutras during their sit-in demanding the abolition of nuclear power plants in front of the prime minister's official residence in Tokyo Thursday, April 14, 2011. (Koji Sasahara)
Mikio Tadano, Sumire sa fille de 16 ans et sa femme Noriko résidents de Futaba sont photographiés dans un centre d'évacuation de Fukushima, au nord est du Japon.
Ayant survécu au séisme et au tsunami du 11 Mars 2011, la région de Futaba était presque intacte,
mais des milliers d’habitants ont dû être évacués en extrême urgence de la ville à la suite des sirènes d’alertes aux radiations issues de la centrale nucléaire de Fukushima Daiichi. (Hiro Komae)
Futaba residents Mikio Tadano, his daughter Sumire, 16, and his wife Noriko are photographed at an evacuation center in Fukushima, northeastern Japan.
Having survived the March 11, 2011 earthquake and tsunami, most of Futaba was intact,
but thousands had to evacuate the city in the wake of the radiation warnings from the neighboring Fukushima Dai-ichi Nuclear power station. (Hiro Komae)
Les habitants du village de Litate écoutent (ndlr: leurs vies va basculer) Norio Sugano leur Maire, à droite de dos, leur expliquer le plan gouvernemental d’évacuation immédiate à cause
des fortes quantités de rayonnements dans leur village qui est à environ 40 kilomètres (24 miles) de la centrale nucléaire de Fukushima Daiichi nucléaires. Mercredi 13 avril 2011. (Kyodo News)
Residents of Litate village listen to Mayor Norio Sugano,right back to camera, explain a government plan to evacuate residents from
the village that's about 40 kilometers (24 miles) from the radiation-spewing Fukushima Daiichi nuclear plant. Wednesday April 13, 2011. (Kyodo News)
SANTÉ PUBLIQUE | PUBLIC HEALTH |
Effets sur la santé des radiations en fonctions de la dose (monographie)
Actuellement dans le monde l’essentiel est l’inhalation ou ingérer des particules radioactives.
Le contrôle de la radioactivité par des balises ne sert strictement à rien (IRSN), c’est de la basse désinformation des populations.
Air Filtration System (particles) / Systèmes de filtration d'air (particules)
In Progress


This study by researchers at the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James) found that inflammation stimulates a rise in levels of a molecule called microRNA-155 (miR-155).
This, in turn, causes a drop in levels of proteins involved in DNA repair, resulting in a higher rate of spontaneous gene mutations, which can lead to cancer.
"Our study shows that miR-155 is upregulated by inflammatory stimuli and that overexpression of miR-155 increases the spontaneous mutation rate, which can contribute to tumorigenesis," says first author and post-doctoral researcher Dr. Esmerina Tili. "People have suspected for some time that inflammation plays an important role in cancer, and our study presents a molecular mechanism that explains how it happens."
"Our findings also suggest that drugs designed to reduce miR-155 levels might improve the treatment of inflammation-related cancers," Tili says.
The findings were published recently in the Proceedings of the National Academy of Sciences.
MicroRNAs form a large family of non-coding genes involved in many important cell processes. They carry out this function by suppressing the amount of particular proteins in cells, with each type of microRNA often affecting many different proteins.
MiR-155 is known to influence blood-cell maturation, immune responses and autoimmune disorders, and high levels of this molecule have been directly linked to the development of leukemias, and breast, lung and gastric cancers.
For this study, Tili and her colleagues examined the effects of inflammation-promoting substances such as tumor necrosis factor or lipopolysaccharide (found in the outer walls of bacteria) on miR-155 expression and on the frequency of spontaneous mutations in several breast-cancer cell lines.
When the researchers exposed breast-cancer cells to the two inflammatory factors the levels of miR-155 rose abnormally high, and the mutation rate increased two- to three-fold. To understand why, the investigators focused on the WEE1 gene, which stops the process of cell division to allow damaged DNA to be repaired.
The investigators learned that miR-155 also targets WEE1 and showed that high levels of miR-155 lead to low levels of WEE1. They reasoned that low levels of WEE1 allowed cell division to continue even when DNA damage is present, leading to a growing number of mutations.
"It is believed that cancer is caused by an accumulation of mutations in cells of the body," says principal investigator Dr. Carlo M. Croce, professor and chair of molecular virology, immunology and medical genetics, and director of the Human Cancer Genetics program the OSUCCC -- James. "Our study suggests that miR-155, which is associated with inflammation, increases the mutation rate and might be a key player in inflammation-induced cancers generally. This could make it an important therapeutic target."
Funding from the National Cancer Institute supported this research.
Croce is also the John W. Wolfe Chair in Human Cancer Genetics.
Other researchers involved in this study were Jean-Jacques Michaille, Dorothee Wernicke, Hansjuerg Alder, Stefan Costinean and Stefano Volinia of The Ohio State University.
