Monday, January 2, 2012

Advaxis Biotech Immunotherapies for Cervical Cancer Trials Results On Board for 2012 As Additional Trial Enrollments Begin

This is a recent video interview with the CEO of Advaxis giving an update on where they are with with their immunotherapies.  As you can see they are going beyond breast and cervical cancer with neck and prostate cancer projects on the agenda. 

The company was able to raise enough money this year to “feed the clinical trials machine” as he calls it to keep this important research alive and well.  Biotech companies are struggling to catch all the funding they need at times and this is something we all need to be aware of.  BD

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Advaxis (ADXS: OTCBB) is a biotechnology company developing the next generation of immunotherapies for cancers and infectious diseases. Advaxis immunotherapies are based on a novel platform technology using live, attenuated bacteria that are bio-engineered to secrete an antigen/adjuvant fusion protein that redirects the powerful immune response all human beings have to the bacteria to the cancer itself. SNNLive met with Tom Moore, CEO of Advaxis at the National Investment Banking Association Conference in Las Vegas 2011.

http://stocknewsnow.com/?p=2646

Evidence grows of links between oral health and overall health

"The eyes may be the window to the soul, but the mouth provides an even better view of the body as a whole," The Wall Street Journal's Melinda Beck writes in her Health Journal column. "Some of the earliest signs of diabetes, cancer, pregnancy, immune disorders, hormone imbalances and drug issues show up in the gums, teeth and tongue—sometimes long before a patient knows anything is wrong. There's also growing evidence that oral health problems, particularly gum disease, can harm a patient's general health as well, raising the risk of diabetes, heart disease, stroke, pneumonia and pregnancy complications." (WSJ graphic; click on it for larger version)
Beck adds, "Such findings are fueling a push for dentists to play a greater role in patients' overall health. Some 20 million Americans — including 6 percent of children and 9 percent of adults — saw a dentist but not a doctor in 2008, according to a study in the American Journal of Public Health this month."

Beck urges her readers not to be fooled by shiny white teeth. "In fact, many dentists worry that people who whiten their teeth may have a false sense of complacency, since their teeth can still be harboring tooth decay and serious gum disease," she writs. "Even people who have no cavities can still have inflamed and infected gums." She quotes Mark Wolff, an associate dean at the New York University College of Dentistry: "Whiteness and the health of your teeth are totally unrelated." (Read more)

High-Fat Diets, Obesity and Brain Damage

Many of you have probably heard the news this week:

High-fat diet may damage the brain
Eating a high-fat diet may rapidly injure brain cells
High fat diet injures the brain
Brain injury from high-fat foods

Your brain cells are exploding with every bite of butter!  Just kidding.  The study in question is titled "Obesity is Associated with Hypothalamic Injury in Rodents and Humans", by Dr. Josh Thaler and colleagues, with my mentor Dr. Mike Schwartz as senior author (1).  We collaborated with the labs of Drs. Tamas Horvath and Matthias Tschop.  I'm fourth author on the paper, so let me explain what we found and why it's important.  

The Questions

Among the many questions that interest obesity researchers, two stand out:
  1. What causes obesity?
  2. Once obesity is established, why is it so difficult to treat?
Our study expands on the efforts of many other labs to answer the first question, and takes a stab at the second one as well.  Dr. Licio Velloso and collaborators were the first to show in 2005 that inflammation in a part of the brain called the hypothalamus contributes to the development of obesity in rodents (2), and this has been independently confirmed several times since then.  The hypothalamus is an important brain region for the regulation of body fatness, and inflammation keeps it from doing its job correctly.

The Findings

Read more »

Pure hydrocodone pain pill in testing; critics worry about abuse

A new pain pill, one more powerful than OxyContin and 10 times stronger than Vicodin, is being tested on patients by four drug companies and could be out as early as 2013. The new medicine, which is a pure form of hydrocodone, has law enforcement in Eastern Kentucky worried, reports Ralph B. Davis of the Floyd County Times.

"In my personal opinion, a drug like that shouldn't be a prescription medication," Floyd County Coroner Greg Nelson told the Times. "It should strictly be an in-house medication."

Drug maker Zogenix of San Diego plans to apply early next year to begin marketing Zohydro, a time-released drug intended to manage moderate to severe pain, reports Chris Hawley of The Associated Press. The drug has completed three rounds of testing.

Critics worry abusers will simply crush the pill to get an intense, immediate high. "I have a big concern that this could be the next OxyContin," said April Rovero, president of the National Coalition Against Prescription Drug Abuse.

The companies defend the drug by saying pure hydrocodone "would avoid liver problems linked to high doses of acetaminophen, an ingredient in products like Vicodin," Hawley reports. "They also say patients will be more closely supervised because, by law, they will have to return to their doctors each time they need more pills."

But critics remain unconvinced and are worried about the larger ramifications of the pills being on the market. "Hydrocodone abuse is already a tremendous problem in Southern and Eastern Kentucky," Karen Kelly, executive director of the government-funded anti-drug program UNITE, told Davis. "When used properly, these medications help many who are experiencing moderate to severe pain. Unfortunately, we have seen how easily the system can be abused."

Davis expressed his own views in an editorial that ran earlier this week. "The pharmaceutical companies developing Zohydro and other copycat drugs clearly must know that their products will kill people," he wrote. "They see it happening every single day. And they have been warned that the problem is growing worse."

Davis referred to a report by the Centers for Disease Control and Prevention, which found that in 2008, an average of 40 people a day in the United States died as a result of prescription painkiller overdoses, a 400 percent increase over 10 years. "Meanwhile, the pharmaceutical companies raked in billions in profits, and financial speculators are taking note," Davis writes. "Since stories about concerns over Zohydro first began appearing over the weekend, Zogenix's stock has skyrocketing nearly 70 percent ... To put it bluntly, this is horrifying." (Read more)

Sunday, January 1, 2012

HealthVault on Windows Phone Mobile Made Possible by iTriage, a Wholly Owned Subsidiary of Aetna

Here’s one more acquisition from Aetna in the Health IT area and it appears that down the road, connecting to Aetna’s PHR they provide to get this data back into their files could be in the works, but you have a choice here to say yes or not.  I imageremember when HeatlhVault was announced, former CEO of Aetna said publicly that Microsoft had no idea what they were doing and could not do it as well as an insurance company, well that was a about 3 years ago or a little more and now look at what’s happening.  It’s all about the data and risk assessments from the insurance side. 

You can almost guess too that Aetna will be using the developers to create more mobile apps that will get more patient data into their files, so just be aware and I’ll keep my HeatlhVault file separate and closed off from any insurer to access with any data connections for sure.  I can always share what I want or provide an exported spread sheet so no worried there and don’t want insurers poking around in my PHR for now. 

If you watch a little television of late you can see the advertisements from Aetna talking about their PHR and wooing consumers into the data game. As insurer contracts get more complicated and complex it’s rolling over to the consumer to find out where you can go, who can see and what will be paid, no wonder they wanted a mobile arm here to develop even more software for smart phones. I did put the application on my Windows Phone but now I’m thinking about taking it off…maybe.  I’ll see how often I use it. 

HealthVault Free Mobile App For Windows Phone Is Out from the Zune Store To Download & Got My Ducks Updated

Not only in this instance but in other areas it’s interesting to see how the health insurers are moving into Health IT and who they are choosing to acquire and partner with.  BD

Insurance giant Aetna has purchased Lakewood-based Healthagen, developer of iTriage, a mobile application that helps injured or sick people determine what's wrong and find local treatment.

Healthagen co-founder Peter Hudson confirmed the deal Monday after Aetna officials announced it during an investor-day event last week. Terms for the transaction, which occurred during the fall, were not disclosed.

Healthagen has been growing quickly, with downloads of its free iTriage app for Apple and Android phones exceeding 3 million, triple the number just a year ago.

http://www.denverpost.com/business/ci_19582144

Government Research Dollar Fee Starts This Year With Health Insurance Plans to Cover Medical Drug Research–Comparing Generics & Name Brand Drugs-Insurers Will Use To Fine Tune Employer Provided Health Plans

The article states that insurers may get a free walk this year but the organization has been started and carriers a .org address.  This is not to replace doctor and patient decisions it states, but what type of influence it will have remains to be imageseen.  This is not a big charge for insurers to pay at a $1 per head but you can completely understand why the insurers will gladly pay as they get more data. 

I just really wonder if this research entity is already outdated as it was created with healthcare reform and in 2 years things have changed a lot and insurers do their own analytics at a much greater cost so for a one buck they can get even more data based on research that is supposed to offer guidelines.  This is an effort to make evidence available for all, but again insurers will combine the data with algorithms to create even more risk savvy parameters for patients to meet when it comes to who they can see and where they go.  One buck is a cheap price for such information.  Also there are rules whereby HHS can only go so far with the data offered as well. 

I don’t know about you but I see this again as a waste and already dated, good when reform was created but little use to day other than to give insurers more data to work with for greater profits as they have evolved in the last 2 years.  When we talk about contracts, look at all the folks who can’t go to Walgreens anymore who have Blue Cross/Wellpoint. 

Anthem Blue Cross Members Will No Longer Be Able to Fill Prescriptions at Walgreens After January 1, 2012

Walgreens wants to sell insurance though anyway.

Walgreens Selling Health Insurance? The Question Still Rambles On and Which One Would They Sell First? United? Both Already Have a Number of Joint Collaborations

This provision and fee will just make it worse and a buck a head is not going to cover even one tenth of the cost as I read it here, so again this one is a loser.  The article builds it up to be “patient centric” but it is “health insurance centric” for sure, and the patient centric claims come from those who are digitally illiterate by all means and don’t get the data trails and use of analytics are they are used and written today.  BD 

Starting in 2012, the government will charge a new fee to your health insurance plan for research to find out which drugs, medical procedures, tests and treatments work best. But what will Americans do with the answers?

The goal of the research, part of a little-known provision of President Barack Obama's health care law, is to answer such basic questions as whether that new prescription drug advertised on TV really works better than an old generic costing much less.

The Patient-Centered Outcomes Research Institute — a quasi-governmental agency created by Congress to carry out the research — has yet to commission a single head-to-head comparison, although its director is anxious to begin.  The institute's director, Dr. Joe Selby, said patients and doctors will make the decisions, not his organization.

"We are not a policy-making body; our role is to make the evidence available," said Selby, a primary care physician and medical researcher.  But insurance industry representatives say they expect to use the research and work with employers to fine-tune workplace health plans. Employees and family members could be steered to hospitals and doctors who follow the most effective treatment methods. Patients going elsewhere could face higher copayments, similar to added charges they now pay for "non-preferred" drugs on their insurance plans.

As a result, lawmakers hedged the new institute with caveats. It was set up as an independent nonprofit organization, with a .org Internet address instead of .gov. The government cannot dictate Selby's research agenda. And there are limitations on how the Health and Human Services department can use the research findings in decisions that affect Medicare and Medicaid.

http://www.nydailynews.com/life-style/health/fee-hit-health-insurance-plan-gov-t-charge-extra-medical-drug-research-article-1.997352

Kraft and Intel Launch “Smart Vending Machines” Using Facial Recognition–Adults Get a Treat But No Kids Allowed - Video

This is an interesting machine and watch the video here.  This is just the start of things to come with facial recognition and how long before vending machines tell if imageyour BMI is over the edge and won’t serve you:)  You don’t think that’s coming, well guess again.  I don’t know if cigarette machines still exist or not since I have not seen one around in years but that would be a beneficial use if I could think of one.

The treats are from Jello but when looking at the menu in the video it doesn’t appear that the samples are straight Jello and may have higher sugar contents.  This kind of imagereminds me of something from the past to where teenagers would wait outside a liquor store and hope they could bribe an adult into making a purchase for them as that’s what would occur here as well if these machines become main place in society. 

The poor kids that try it though, look at the message, not really kind at all. Is this another “attack of the killer algorithms” that discriminate?  If any of you thought I was kidding with my 7 part series, here’s more proof that they have “teeth” and do exist.  BD   

Facial Recognition Vending Machines

Intel and Kraft have partnered to launch smart vending machines, called iSample. The machines contain an optical sensor that that can recognize and scan a human face. The software in the machines uses data from the facial scan and computer algorithms to determine the age of the person standing at the machine.

http://www.sciencenewsblog.com/blog/10120121

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